Dr. Piyush Mathur, MD, FCCM, FASA, FAMIA, is an Associate Professor of Anesthesiology at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University and a practicing anesthesiologist–intensivist at Cleveland Clinic. He currently serves as Innovation Lead for the Department of Anesthesiology and has held longstanding leadership roles including Quality Improvement Officer and Chair of the Anesthesiology Institute Compliance Committee. He previously served as Program Director of the Anesthesiology Critical Care Fellowship and has led curriculum development across fellowship, residency, and inter-professional education programs. With more than two decades of academic and clinical experience, Dr. Mathur has led major institutional initiatives focused on patient safety, perioperative quality, and large-scale clinical and digital innovation.

Dr. Mathur is internationally recognized for his work at the intersection of artificial intelligence, machine learning, and critical care medicine, with particular emphasis on generative AI and large language models (LLMs). He has pursued extensive formal training in artificial intelligence, machine learning, natural language processing, and data science including coursework in neural networks, deep learning, NLP, graph neural networks, retrieval-augmented generation, and agentic AI. His scholarship includes influential peer-reviewed publications in venues such as Critical Care Medicine and npj Health Systems, advancing rigorous methods for evaluation, validation, and human-centered assessment of LLMs and other AI systems in real-world clinical settings. He has authored three books and contributed numerous book chapters and invited scholarly work addressing artificial intelligence, perioperative medicine, quality improvement, and digital health, helping translate complex computational concepts into practical guidance for clinicians and healthcare leaders.

Co-founder of BrainX and the BrainX Community, Dr. Mathur has built a global, multidisciplinary platform dedicated to advancing responsible, evidence-based AI in healthcare through education, collaboration, and translational research. A committed academic and thought leader, he serves on multiple national and international committees across the Society of Critical Care Medicine, American Medical Informatics Association, American Medical Association, and the American Board of Artificial Intelligence in Medicine. His contributions have been recognized with numerous Innovator Awards, Presidential Citations from SCCM, and the 2025 AI Clinician of the Year Award.

Dr. Mathur’s combined expertise in clinical medicine, AI research, and education positions him uniquely to lead multidisciplinary, translational research programs that prioritize patient safety, scientific rigor, and workforce development. His work directly supports priorities in data-driven healthcare innovation, responsible AI adoption, and the training of the next generation of clinician–scientists capable of bridging medicine, data science, and health systems improvement.